Brand Names: Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban SR
Generic Name: bupropion hydrochloride
What is Wellbutrin used for? Bupropion hydrochloride is an antidepressant
of the aminoketone class that is chemically unrelated to tricyclic, selective
serotonin re-uptake inhibitor or other antidepressants. Wellbutrin is used to
treat depression while Zyban is used as a smoking cessation aid.
FDA Warnings for Wellbutrin: The FDA issued a public health alert for
Wellbutrin in March 2004 warning that bupropion hydrochloride can lead to deeper
depression and suicide. The FDA recommends that health care providers warn
patients, their families and their caregivers to be alert for agitation,
irritability, suicide and worsening depression while using Wellbutrin. The FDA
also recommends that health care providers closely monitor adult and children
treated with bupropion hydrochloride for worsening of depression or suicidal
tendencies, especially at the beginning of therapy or when the dose either
increases or decreases.
General Wellbutrin Precautions:
_ Wellbutrin can be habit forming.
_ Talk to your doctor about alcohol use before starting treatment with bupropion
hydrochloride. Alcohol may increase the risk of having a seizure while taking
bupropion. Avoid alcohol or drink it only in moderation while taking Wellbutrin.
_ Never take more bupropion hydrochloride than is directed by your doctor.
Higher doses of bupropion hydrochloride may increase the risk of a seizure.
_ Wellbutrin may cause dizziness. If you experience dizziness, avoid driving,
operating machinery, or performing other hazardous activities.
_ Rise slowly when rising from a sitting or lying position to prevent dizziness
or possible falls.
_ Do not take Wellbutrin if you have taken a monoamine oxidase inhibitor (MAOI)
within the last 14 days. A dangerous drug interaction can occur if bupropion
hydrochloride is combined with MAO inhibitors.
_ It is not known whether Wellbutrin will harm an unborn or nursing baby. Do not
take Wellbutrin if you are pregnant or could become pregnant without first
talking to your doctor.
_ Tell the doctor or dentist that you are taking Wellbutrin if you are having
surgery, including dental surgery.
_ Wellbutrin may impair judgment, thinking, or motor skills. Patients using
bupropion should exercise caution until they have adapted to therapy.
_ If you skip the missed dose and take only the next one as directed. Do not
take a double dose of Wellbutrin. Overdose is possible.
_ Too much bupropion hydrochloride can increase the risk of a seizure. Do not be
taking more than one product containing bupropion hydrochloride at a time (Wellbutrin
and Zyban SR).
_ Wellbutrin has been linked to Parkinson's Disease.
Wellbutrin can cause serious side effects. Only you can decide if Wellbutrin is
the best means of treating depression symptoms. It is important for people
currently taking Wellbutrin to discuss side effect concerns with their
Wellbutrin Side Effects:
_ Deepened depression.
_ Increased risk of suicide.
_ Rapid or irregular heartbeats.
_ Chest pain.
_ Shortness of breath.
_ Insomnia or sleeplessness.
_ Change in sex drive or ability.
_ Loss of libido.
_ Difficulty urinating or frequent urination.
_ Dry mouth.
_ Weight gain or weight loss.
_ Excessive sweating.
_ Skin rash.
_ Ringing in the ears.
_ Flu-like symptoms such as aching muscles, fatigue, and discomfort.
_ Blurred vision.
_ Loss of coordination.
_ Muscle or joint pain.
Contact your doctor immediately if you experience: An allergic reaction
(difficulty breathing; closing of the throat; swelling of the lips, face, or
tongue; or hives). Stop taking Wellbutrin and contact your doctor immediately or
seek emergency medical treatment if you also experience a fast or irregular
heartbeat or seizures. Contact your doctor immediately if you experience
yellowing of the skin or eyes.
Symptoms of overdose may include: Symptoms of a Wellbutrin overdose
include seizures, loss of consciousness, weakness, hallucinations, rapid or
irregular heartbeat, heart attack, difficulty breathing or swallowing,
dizziness, fainting, confusion and blurred vision.
Before taking Wellbutrin, tell your doctor if you have or ever had:
_ Seizures or epilepsy.
_ Head injury or brain or spinal column tumor.
_ Liver disease.
_ Kidney disease.
_ Heart disease.
_ High blood pressure.
_ History of heart attack.
_ Suicidal thoughts.
_ Anorexia, bulimia or other eating disorders.
_ Drink alcohol.
_ Use street drugs or take a prescription benzodiazepine such as Xanax, Valium
_ Enlarged prostate.
_ Difficulty urinating.
_ An overactive thyroid gland.
What should I avoid while taking Wellbutrin?
_ Alcohol may increase the risk of having a seizure while taking Wellbutrin.
Avoid alcohol or drink it only in moderation while taking Wellbutrin.
_ Never take more Wellbutrin than is directed by your doctor. Higher doses of
bupropion hydrochloride may increase the risk of a seizure.
What other drugs will affect bupropion? Wellbutrin can increase the
effects of many other drugs, leading to serious side effects. If taking
Wellbutrin, talk to your doctor and pharmacist before taking any prescription or
over-the-counter medicines. Do not take bupropion hydrochloride with the
following medicines without your doctor’s approval:
_ Other bupropion hydrochloride products.
_ MAO inhibitors.
_ Other antidepressants.
Wellbutrin can also interfere with anticoagulants, antihistamines,
antipsychotics, diet pills, medication for high blood pressure, seizures,
asthma, colds, or allergies; oral anti-diabetic medications, sedatives, sleeping
pills, thyroid medications, tranquilizers, and vitamins. Drugs other than the
above listed may also interact with Wellbutrin. Talk to your doctor and
pharmacist before taking any prescription, over-the-counter medicines or natural
People seeking depression relief should carefully evaluate Wellbutrin
information and side effects before deciding to take Wellbutrin. Consult your
healthcare professional before using Wellbutrin.
The natural antidepressant Deprex is a safe and effective depression treatment
scientifically formulated to elevate mood without the potentially harmful side
effects commonly associated with Wellbutrin. Self-help techniques,
psychotherapy, diet and lifestyle changes or a combination of approaches have
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If you want to eliminate depression and start living a more fulfilling and
satisfying life without the cost or side effects of prescription depression
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*This antidepressant drug information does not endorse Wellbutrin, diagnose
patients or recommend therapy. The information contained herein is not intended
to cover all possible warnings, uses, precautions, drug interactions, allergic
reactions, or adverse side effects of Wellbutrin. If you have questions about
the drugs you are taking, check with your health care provider or pharmacist.
The information provided should not be construed to indicate that Wellbutrin is
safe, effective or appropriate.
Do not stop taking Wellbutrin without first talking to your doctor. Your doctor
may need to gradually reduce the dose before stopping Wellbutrin completely.
Suddenly stopping bupropion hydrochloride may cause unpleasant and potentially
serious side effects.
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